Sensor to detect endothelialization on an active coronary stent

Sensor to detect endothelialization on an active coronary stent

BACKGROUND A serious complication with drug-eluting coronary stents is late thrombosis, caused by exposed stent struts not covered by endothelial cells in the healing process. Real-time detection of this healing process could guide physicians for more individualized anti-platelet therapy. Here we present work towards developing a sensor to detect this healing process. Sensors on several stent s...

Delayed endothelialization after polytetrafluoroethylene-covered stent implantation for coronary aneurysm.

A polytetrafluoroethylene (PTFE)-covered stent is specially used to treat coronary perforation complicating percutaneous intervention in order to prevent the aneurysm from rupturing, but until now it has not been known if endothelialization occurs inside this type of stent. A patient with a giant aneurysm of the right coronary artery underwent successful implantation of a PTFE-covered stent. An...

Engineering Calpastatin to Develop a Sensor to Detect Active Calpain

Assessment of stent strut endothelialization in iliac arteries of rabbits.

BACKGROUND Fast post-implantation stent endothelialization is desirable for theoretically reducing the possibility of stent thrombosis. OBJECTIVE To evaluate the extent of sirolimus-eluting stent strut endothelialization (delivered from the luminal and abluminal aspects or abluminal aspect only) in the iliac arteries of rabbits. METHODS The iliac arteries of 10 rabbits were implanted with f...

Bioactive baculovirus nanohybrids for stent based rapid vascular re-endothelialization

Present study, for the first time, reports the development of a nanohybridized baculovirus based stent that can locally promote vascular re-endothelialization by efficient delivery of pro-angiogenic vascular endothelial growth factor (Vegf) genes. In vitro data demonstrated rapid expression of functionally active Vegf by the bioactive stent-transduced vascular cells. In vivo site-specific trans...